WISDOM PANELTM 4.0

CANINE BREED DETECTION

$84.99
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Unfold the Secrets of Your Dog’s DNA

WISDOM PANEL is the world's leading DNA test for dogs. Our database includes 250+ breeds, types and varieties—the largest number on the market—making us not only accurate and reliable, but trusted by more than 850,000 pet parents the world over. In addition to breed identification, your customized, online report will provide you with:

  • Percentage breakdown of breeds and breed groups found in your dog
  • A detailed family tree going back three generations
  • Extensive information about each breed and breed group found
  • A predicted weight profile
  • Potentially life-saving drug sensitivity screening for MDR1
  • Results for Exercise-induced Collapse screening
  • A genetic trait analysis
  • The ability to share your results with your veterinarian
  • A unique discount code to share with friends or family!

    How It Works

    logo

    Swab your dog’s cheek to collect DNA.

    Activate your kit online.

    Mail in the test. Shipping is free!

    Receive results in 2-3 weeks.

    Reviews

    Health Screening

    The WISDOM PANEL 4.0 test offers these important genetic health screenings:

    Looking for more health testing? Check out the WISDOM PANEL Health Test with 150+ genetic health screens.

    MDR1 Disease Screening 1 Screening

    Clinical Overview

    Multi-drug Resistance 1 (MDR1) is a genetic mutation found in many of the herding breeds, some sighthound breeds, and many mixed breed dogs. The MDR1 gene is responsible for production of a protein called P-glycoprotein. The P-glycoprotein molecule is a drug transport pump that plays an important role in limiting drug absorption and distribution (particularly to the brain) and enhancing the excretion/elimination of many drugs used in dogs.

    Some dogs, particularly herding breeds or mixed-breed dogs with herding breed ancestry, have a mutation in the MDR1 gene that makes them defective in their ability to limit the absorption and distribution of many drugs. These dogs are also slower to eliminate drugs from the body that are transported by P-glycoprotein. As a result, dogs with the MDR1-mutation may have severe adverse reactions to some common drugs, so it is important to test your dog and share your results with your veterinarian so they can provide your dog with for the best possible care.

    Drugs Affected by the MDR1 Mutation:

    • Acepromazine
    • Butorphanol
    • Doxorubicin
    • Doramectin
    • Doramectin
    • Emodepside
    • Erythromycin
    • Ivermectin
    • Loperamide
    • Milbemycin
    • Moxidectin
    • Paclitaxel
    • Rifampin
    • Selamectin
    • Vinblastine
    • Vincristine

    Drugs Affected by the MDR1 Mutation (frequency %):

    • Australian Shepherd 50%
    • Australian Shepherd, Mini 50%
    • Border Collie < 5%
    • Collie 70%
    • English Shepherd 15%
    • German Shepherd 10%
    • Herding Breed Cross 10%
    • Long-haired Whippet 65%
    • McNab 30%
    • Mixed Breed 5%
    • Old English Sheepdog 5%
    • Shetland Sheepdog 15%
    • Silken Windhound 30%


    FAQs About the MDR1 Mutation

    Can Collie crosses or other herding breed crosses carry the mutant MDR1 gene and have an adverse reaction to a normal dose of some drugs?

    Yes, it is less likely in a mixed breed, but still possible. For example, the mutant gene was found in a Saint Bernard mix that had an adverse drug reaction. The veterinarian did note that each eye was a different colour, like some Australian Shepherds.

    How old must a dog be before it can be tested?

    Just like breed testing, a puppy can be tested as soon as it is weaned from its mother. We recommend waiting until the puppy is weaned, because the sample is collected from inside the dog's mouth, and milk can contain a cells from the mother. Therefore, it is possible that the puppy's sample could contain enough of the mother's DNA to generate a false result.

    Can mixed-breed dogs have the MDR1 mutation?

    YES! Even if we don't find a pedigree herding or sighthound breed in the last three generations of your dog's family tree, doesn't mean he or she doesn't have one further back in their ancestry. Therefore, even mixed-breed dogs should be tested for the MDR1 mutation¬¬-in particular before receiving therapies for some common parasitic diseases, such as Demodectic mange. The results of this test can give owners with mixed-breed ancestry important information to share with their veterinarian or better yet…peace of mind. 

    What heartworm prevention products can I use if my dog has the MDR1 mutation?

    Always consult with your veterinarian before administering any drugs to your dog. Fortunately, the doses of ivermectin, selamectin, milbemycin and moxidectin in the FDA approved heartworm prevention preparations are low enough to be used safely even in dogs that have two copies of the MDR1 mutation. It is only when these drugs are administered at high doses that dogs with the mutation will develop signs of toxicity. Attempting to use formulations of these drugs approved for use in large animals will increase the risk of overdosing the dog and causing severe toxicity, because it is difficult to accurately measure the small doses needed for dogs using these large animal formulations.

    Origins of the Test

    The discovery of the mutation of the multi-drug resistant gene (MDR1) and its effects on multidrug sensitivity in dogs was made by Washington State University. It is a patent-protected diagnostic test offered by Washington State University that has been licensed to Wisdom Health for use in the WISDOM PANEL tests.

    Exercise-induced Collapse (EIC) Screening

    Clinical Overview

    Exercise-induced collapse (EIC) is an inherited disorder of nerve and muscle that was first identified in Labrador Retrievers. It is caused by a mutation in the DNM1 gene, and is characterized by exercise intolerance in otherwise normal dogs.

    Clinical Signs and Severity

    Signs are usually first noted in young dogs, most frequently between 5 months and 3 years of age. Affected dogs appear normal during low to moderate exercise, but develop clinical signs including weakness, wobbliness, and incoordination after strenuous exercise, particularly in the hind limbs. In severe cases, short-term full body collapse and muscle weakness can be noted. The episodes typically last 5-10 minutes, and most dogs will recover completely within 15-30 minutes.

    Severity of the disorder is mild to moderate for the majority of dogs. Dogs are not in pain during collapse or after recovery. Affected dogs are generally unable to continue training or competition, but can live relatively normal lives if exercise and excitement are limited.

    Factors Contributing to Collapse in Affected Dogs

    • Ambient temperature or humidity is much higher than what the dog is used to
    • Extreme excitement or stress
    • Exercise that is continuous, intense, and accompanied by high-level excitement or anxiety

    Commonly Affected Breeds

    • Boykin Spaniel
    • Chesapeake Bay Retriever
    • Curly Coated Retriever
    • Labrador Retriever
    • Old English Sheepdog
    • Pembroke Welsh Corgi
    • German Wirehaired Pointer
    • Mixed-breed dogs

     

     

    Breeds Detected

    The more breeds you have in your database to detect, the more accurate your results. WISDOM PANEL has the largest breed database on the market with more than 250 breeds, types and varieties represented in 15,000 samples. Check out the full list of breeds below:


    Foreign Breeds?

    The WISDOM PANEL tests were developed using pure breeds primarily found on The Kennel Club and the American Kennel Club registry lists. If your dog was imported from a country other than the US, Canada, Western or Northern Europe, or you suspect that your dog’s ancestors are from outside these countries/areas, his breed ancestry may not be as well represented in our database.

    The WISDOM PANEL 4.0 test offers these important genetic health screenings:

    Looking for more health testing? Check out the WISDOM PANEL Health Test with 150+ genetic health screens.

    Clinical Overview

    Multi-drug Resistance 1 (MDR1) is a genetic mutation found in many of the herding breeds, some sighthound breeds, and many mixed breed dogs. The MDR1 gene is responsible for production of a protein called P-glycoprotein. The P-glycoprotein molecule is a drug transport pump that plays an important role in limiting drug absorption and distribution (particularly to the brain) and enhancing the excretion/elimination of many drugs used in dogs.

    Some dogs, particularly herding breeds or mixed-breed dogs with herding breed ancestry, have a mutation in the MDR1 gene that makes them defective in their ability to limit the absorption and distribution of many drugs. These dogs are also slower to eliminate drugs from the body that are transported by P-glycoprotein. As a result, dogs with the MDR1-mutation may have severe adverse reactions to some common drugs, so it is important to test your dog and share your results with your veterinarian so they can provide your dog with for the best possible care.

    Drugs Affected by the MDR1 Mutation:

    • Acepromazine
    • Butorphanol
    • Doxorubicin
    • Doramectin
    • Doramectin
    • Emodepside
    • Erythromycin
    • Ivermectin
    • Loperamide
    • Milbemycin
    • Moxidectin
    • Paclitaxel
    • Rifampin
    • Selamectin
    • Vinblastine
    • Vincristine

    Drugs Affected by the MDR1 Mutation (frequency %):

    • Australian Shepherd 50%
    • Australian Shepherd, Mini 50%
    • Border Collie < 5%
    • Collie 70%
    • English Shepherd 15%
    • German Shepherd 10%
    • Herding Breed Cross 10%
    • Long-haired Whippet 65%
    • McNab 30%
    • Mixed Breed 5%
    • Old English Sheepdog 5%
    • Shetland Sheepdog 15%
    • Silken Windhound 30%


    FAQs About the MDR1 Mutation

    Can Collie crosses or other herding breed crosses carry the mutant MDR1 gene and have an adverse reaction to a normal dose of some drugs?

    Yes, it is less likely in a mixed breed, but still possible. For example, the mutant gene was found in a Saint Bernard mix that had an adverse drug reaction. The veterinarian did note that each eye was a different colour, like some Australian Shepherds.

    How old must a dog be before it can be tested?

    Just like breed testing, a puppy can be tested as soon as it is weaned from its mother. We recommend waiting until the puppy is weaned, because the sample is collected from inside the dog's mouth, and milk can contain a cells from the mother. Therefore, it is possible that the puppy's sample could contain enough of the mother's DNA to generate a false result.

    Can mixed-breed dogs have the MDR1 mutation?

    YES! Even if we don't find a pedigree herding or sighthound breed in the last three generations of your dog's family tree, doesn't mean he or she doesn't have one further back in their ancestry. Therefore, even mixed-breed dogs should be tested for the MDR1 mutation¬¬-in particular before receiving therapies for some common parasitic diseases, such as Demodectic mange. The results of this test can give owners with mixed-breed ancestry important information to share with their veterinarian or better yet…peace of mind. 

    What heartworm prevention products can I use if my dog has the MDR1 mutation?

    Always consult with your veterinarian before administering any drugs to your dog. Fortunately, the doses of ivermectin, selamectin, milbemycin and moxidectin in the FDA approved heartworm prevention preparations are low enough to be used safely even in dogs that have two copies of the MDR1 mutation. It is only when these drugs are administered at high doses that dogs with the mutation will develop signs of toxicity. Attempting to use formulations of these drugs approved for use in large animals will increase the risk of overdosing the dog and causing severe toxicity, because it is difficult to accurately measure the small doses needed for dogs using these large animal formulations.

    Origins of the Test

    The discovery of the mutation of the multi-drug resistant gene (MDR1) and its effects on multidrug sensitivity in dogs was made by Washington State University. It is a patent-protected diagnostic test offered by Washington State University that has been licensed to Wisdom Health for use in the WISDOM PANEL tests.

    Clinical Overview

    Exercise-induced collapse (EIC) is an inherited disorder of nerve and muscle that was first identified in Labrador Retrievers. It is caused by a mutation in the DNM1 gene, and is characterized by exercise intolerance in otherwise normal dogs.

    Clinical Signs and Severity

    Signs are usually first noted in young dogs, most frequently between 5 months and 3 years of age. Affected dogs appear normal during low to moderate exercise, but develop clinical signs including weakness, wobbliness, and incoordination after strenuous exercise, particularly in the hind limbs. In severe cases, short-term full body collapse and muscle weakness can be noted. The episodes typically last 5-10 minutes, and most dogs will recover completely within 15-30 minutes.

    Severity of the disorder is mild to moderate for the majority of dogs. Dogs are not in pain during collapse or after recovery. Affected dogs are generally unable to continue training or competition, but can live relatively normal lives if exercise and excitement are limited.

    Factors Contributing to Collapse in Affected Dogs

    • Ambient temperature or humidity is much higher than what the dog is used to
    • Extreme excitement or stress
    • Exercise that is continuous, intense, and accompanied by high-level excitement or anxiety

    Commonly Affected Breeds

    • Boykin Spaniel
    • Chesapeake Bay Retriever
    • Curly Coated Retriever
    • Labrador Retriever
    • Old English Sheepdog
    • Pembroke Welsh Corgi
    • German Wirehaired Pointer
    • Mixed-breed dogs

     

     

    The more breeds you have in your database to detect, the more accurate your results. WISDOM PANEL has the largest breed database on the market with more than 250 breeds, types and varieties represented in 15,000 samples. Check out the full list of breeds below:


    Foreign Breeds?

    The WISDOM PANEL tests were developed using pure breeds primarily found on The Kennel Club and the American Kennel Club registry lists. If your dog was imported from a country other than the US, Canada, Western or Northern Europe, or you suspect that your dog’s ancestors are from outside these countries/areas, his breed ancestry may not be as well represented in our database.